Skip to main content


What is MOTRIN® (Ibuprofen)

From adults to children, MOTRIN® can give your family the relief they need. Many doctors and patients rely on MOTRIN® products when they suffer from aches and pains or have a fever. Helping to reduce fevers and relieve pain, MOTRIN® helps keep you and the ones you love going strong.

How MOTRIN® Compares

With so many choices, choosing a pain reliever can be confusing and overwhelming. When you choose MOTRIN®, you’re really choosing a fever reducer and pain reliever that has provided decades of effective relief.

So what’s the difference between MOTRIN® and TYLENOL®? Both TYLENOL® and MOTRIN® relieve pain and reduce fever, but they work differently.

The active ingredient in MOTRIN® products is ibuprofen, a nonsteroidal anti-inflammatory drug, or NSAID. It works by inhibiting the production of substances that cause inflammation and pain in the body. Ibuprofen is used to reduce fever and treat pain caused by many conditions such as headache, toothache, backache, minor pain from arthritis, menstrual cramps, or muscle aches.

Unlike MOTRIN® products, TYLENOL® products contain the active ingredient acetaminophen, which is not a nonsteroidal anti-inflammatory drug. Acetaminophen is believed to work by elevating the body's overall pain threshold so you feel less pain, and it lowers your fever by helping your body eliminate excess heat.

The History of MOTRIN®

In the U.S., the MOTRIN® story began in 1974, when Ibuprofen first came out as a prescription drug. It was then approved as MOTRIN® IB in the mid-1980s as an over-the-counter pain reliever and fever reducer. And in 1995, Children's MOTRIN® was born and it became a milestone that gave parents a medicine they could rely on when they needed it most.

Learn more about MOTRIN® products.

Get a list of retailers in your area, or buy online.